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1

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 || Design of shRNA and miRNA for Delivery to the CNS

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 392 KB

english, 2016

2

Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology

Manfredsson, Fredric P., Luk, Kelvin C., Benskey, Matthew J., Guezer, Aysegul, Garcia, Joanna, Kuhn, Nathan C., Sandoval, Ivette M., Patterson, Joseph R., O'Mara, Alana, Yonkers, Reid, Kordower, Jeffr

Journal:

Neurobiology of Disease

Year:

2018

Language:

english

File:

PDF, 99.69 MB

english, 2018

3

Glycomic and Proteomic changes in aging brain nigrostriatal pathway

Raghunathan, Rekha, Polinski, Nicole K., Klein, Joshua A., Hogan, John D., Shao, Chun, Khatri, Kshitij, Leon, Deborah R., McComb, Mark E., Manfredsson, Fredric P., Sortwell, Caryl E., Zaia, Joseph

Journal:

Molecular & Cellular Proteomics

Year:

2018

Language:

english

File:

PDF, 796 KB

english, 2018

4

rAAV-mediated nigral human parkin over-expression partially ameliorates motor deficits via enhanced dopamine neurotransmission in a rat model of Parkinson's disease

Fredric P. Manfredsson, Corinna Burger, Layla F. Sullivan, Nicholas Muzyczka, Alfred S. Lewin, Ronald J. Mandel

Journal:

Experimental Neurology

Year:

2007

Language:

english

File:

PDF, 1.56 MB

english, 2007

5

Regulated protein expression for in vivo gene therapy for neurological disorders: Progress, strategies, and issues

Fredric P. Manfredsson, David C. Bloom, Ronald J. Mandel

Journal:

Neurobiology of Disease

Year:

2012

Language:

english

File:

PDF, 583 KB

english, 2012

6

The development of flexible lentiviral vectors for gene transfer in the CNS

Fredric P. Manfredsson, Ronald J. Mandel

Journal:

Experimental Neurology

Year:

2011

Language:

english

File:

PDF, 717 KB

english, 2011

7

Differential sensitivity of cranial and limb motor function to nigrostriatal dopamine depletion

Plowman, Emily K., Maling, Nicholas, Rivera, Benjamin J., Larson, Krista, Thomas, Nagheme J., Fowler, Stephen C., Manfredsson, Fredric P., Shrivastav, Rahul, Kleim, Jeffrey A.

Journal:

Behavioural Brain Research

Year:

2013

Language:

english

File:

PDF, 373 KB

english, 2013

8

The role of parkin in the differential susceptibility of tuberoinfundibular and nigrostriatal dopamine neurons to acute toxicant exposure

Benskey, Matthew J., Manfredsson, Fredric P., Lookingland, Keith J., Goudreau, John L.

Journal:

NeuroToxicology

Year:

2015

Language:

english

File:

PDF, 2.39 MB

english, 2015

9

895. Separate rAAV1 Vectors Co-Infect Striatal Neurons Efficiently

Manfredsson, Fredric P., Rising, Aaron C., Mandel, Ronald J.

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 82 KB

english, 2006

10

1032. rAAV Mediated Knock-Down of Tyrosine Hydroxylase in the Substantia Nigra Using a pol II Transcribed siRNA

Manfredsson, Fredric P., Mandel, Ronald J., Zolotukhin, Sergei, Lewin, Alfred S.

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 83 KB

english, 2006

11

903. Re-Administration of Recombinant AAV2 and AAV5 in the Brain

Reimsnider, Sharon K., Manfredsson, Fredric P., Burger, Corinna, Muzczyka, Nicholas, Mandel, Ronald J.

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 168 KB

english, 2006

12

Recombinant adenoassociated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain

Polinski, Nicole K., Gombash, Sara E., Manfredsson, Fredric P., Lipton, Jack W., Kemp, Christopher J., Cole-Strauss, Allyson, Kanaan, Nicholas M., Steece-Collier, Kathy, Kuhn, Nathan C., Wohlgenant, S

Journal:

Neurobiology of Aging

Year:

2015

Language:

english

File:

PDF, 2.12 MB

english, 2015

13

Targeted Gene Delivery to the Enteric Nervous System Using AAV: A Comparison Across Serotypes and Capsid Mutants

Benskey, Matthew J, Kuhn, Nathan C, Galligan, James J, Garcia, Joanna, Boye, Shannon E, Hauswirth, William W, Mueller, Christian, Boye, Sanford L, Manfredsson, Fredric P

Journal:

Molecular Therapy

Year:

2015

Language:

english

File:

PDF, 3.84 MB

english, 2015

14

AAV9: a potential blood-brain barrier buster

Manfredsson, Fredric P, Rising, Aaron C, Mandel, Ronald J

Journal:

Molecular Therapy

Year:

2009

Language:

english

File:

PDF, 382 KB

english, 2009

15

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

Paumier, Katrina L., Luk, Kelvin C., Manfredsson, Fredric P., Kanaan, Nicholas M., Lipton, Jack W., Collier, Timothy J., Steece-Collier, Kathy, Kemp, Christopher J., Celano, Stephanie, Schulz, Emily,

Journal:

Neurobiology of Disease

Year:

2015

Language:

english

File:

PDF, 3.97 MB

english, 2015

16

Nigrostriatal rAAV-mediated GDNF Overexpression Induces Robust Weight Loss in a Rat Model of Age-related Obesity

Manfredsson, Fredric P, Tumer, Nihal, Erdos, Benedek, Landa, Tessa, Broxson, Christopher S, Sullivan, Layla F, Rising, Aaron C, Foust, Kevin D, Zhang, Yi, Muzyczka, Nicholas, Gorbatyuk, Oleg S, Scarpa

Journal:

Molecular Therapy

Year:

2009

Language:

english

File:

PDF, 1.84 MB

english, 2009

17

Tight Long-term Dynamic Doxycycline Responsive Nigrostriatal GDNF Using a Single rAAV Vector

Manfredsson, Fredric P, Burger, Corinna, Rising, Aaron C, Zuobi-Hasona, Kheir, Sullivan, Layla F, Lewin, Alfred S, Huang, Julia, Piercefield, Emily, Muzyczka, Nicholas, Mandel, Ronald J

Journal:

Molecular Therapy

Year:

2009

Language:

english

File:

PDF, 1.16 MB

english, 2009

18

Time Course of Transgene Expression After Intrastriatal Pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 Transduction in the Rat

Reimsnider, Sharon, Manfredsson, Fredric P, Muzyczka, Nicholas, Mandel, Ronald J

Journal:

Molecular Therapy

Year:

2007

Language:

english

File:

PDF, 690 KB

english, 2007

19

In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration

Gorbatyuk, Oleg S, Li, Shoudong, Nash, Kevin, Gorbatyuk, Marina, Lewin, Alfred S, Sullivan, Layla F, Mandel, Ronald J, Chen, Weijun, Meyers, Craig, Manfredsson, Fredric P, Muzyczka, Nicholas

Journal:

Molecular Therapy

Year:

2010

Language:

english

File:

PDF, 614 KB

english, 2010

20

α-Synuclein Expression in Rat Substantia Nigra Suppresses Phospholipase D2 Toxicity and Nigral Neurodegeneration

Gorbatyuk, Oleg S, Li, Shoudong, Nha Nguyen, Frederic, Manfredsson, Fredric P, Kondrikova, Galina, Sullivan, Layla F, Meyers, Craig, Chen, Weijun, Mandel, Ronald J, Muzyczka, Nicholas

Journal:

Molecular Therapy

Year:

2010

Language:

english

File:

PDF, 791 KB

english, 2010

21

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 ||

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 16.12 MB

english, 2016

22

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 || Expression of Multiple Functional RNAs or Proteins from One Viral Vector

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 380 KB

english, 2016

23

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 || Introduction to Viral Vectors and Other Delivery Methods for Gene Therapy of the Nervous System

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 264 KB

english, 2016

24

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 || Ex Vivo Gene Therapy Using Human Mesenchymal Stem Cells to Deliver Growth Factors in the Skeletal Muscle of a Familial ALS Rat Model

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 649 KB

english, 2016

25

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 || Stereotaxic Surgical Targeting of the Nonhuman Primate Caudate and Putamen: Gene Therapy for Huntington’s Disease

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 633 KB

english, 2016

26

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 || Gene Therapy for the Treatment of Neurological Disorders: Metabolic Disorders

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 493 KB

english, 2016

27

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 || Altering Entry Site Preference of Lentiviral Vectors into Neuronal Cells by Pseudotyping with Envelope Glycoproteins

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 513 KB

english, 2016

28

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 || Gene Therapy for the Treatment of Neurological Disorders: Amyotrophic Lateral Sclerosis

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 187 KB

english, 2016

29

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 || Lentivirus Production and Purification

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 498 KB

english, 2016

30

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 || Small-Scale Recombinant Adeno-Associated Virus Purification

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 226 KB

english, 2016

31

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 || Altering Tropism of rAAV by Directed Evolution

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 560 KB

english, 2016

32

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 || Delivering Transgenic DNA Exceeding the Carrying Capacity of AAV Vectors

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 407 KB

english, 2016

33

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 || Gene Therapy for the Treatment of Neurological Disorders: Central Nervous System Neoplasms

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 728 KB

english, 2016

34

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 || Tissue-Specific Promoters in the CNS

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 286 KB

english, 2016

35

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 || Regulated Gene Therapy

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 320 KB

english, 2016

36

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 || Viral Vector Production: Adenovirus

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 420 KB

english, 2016

37

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 || Non-Viral, Lipid-Mediated DNA and mRNA Gene Therapy of the Central Nervous System (CNS): Chemical-Based Transfection

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 292 KB

english, 2016

38

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 || AAV-Mediated Gene Transfer to Dorsal Root Ganglion

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 545 KB

english, 2016

39

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 || Gene Therapy Models of Alzheimer’s Disease and Other Dementias

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 1.13 MB

english, 2016

40

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 || Viral Vector-Based Modeling of Neurodegenerative Disorders: Parkinson’s Disease

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 673 KB

english, 2016

41

[Methods in Molecular Biology] Gene Therapy for Neurological Disorders Volume 1382 || Systemic Gene Therapy for Targeting the CNS

Manfredsson, Fredric P.

Year:

2016

Language:

english

File:

PDF, 485 KB

english, 2016

42

Striatal Readministration of rAAV Vectors Reveals an Immune Response Against AAV2 Capsids That Can Be Circumvented

Peden, Carmen S, Manfredsson, Fredric P, Reimsnider, Sharon K, Poirier, Amy E, Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J

Journal:

Molecular Therapy

Year:

2009

Language:

english

File:

PDF, 13.50 MB

english, 2009

43

Continuous Collection of Adeno-Associated Virus from Producer Cell Medium Significantly Increases Total Viral Yield

Benskey, Matthew J., Sandoval, Ivette M., Manfredsson, Fredric P.

Journal:

Human Gene Therapy Methods

Year:

2016

Language:

english

File:

PDF, 1.34 MB

english, 2016

44

Quantitative and semi-quantitative measurements of axonal degeneration in tissue and primary neuron cultures

Kneynsberg, Andrew, Collier, Timothy J., Manfredsson, Fredric P., Kanaan, Nicholas M.

Journal:

Journal of Neuroscience Methods

Year:

2016

Language:

english

File:

PDF, 3.13 MB

english, 2016

45

Gene Therapy for Neurological Disorders: Challenges and Future Prospects for the Use of Growth Factors for the Treatment of Parkinsons Disease

Manfredsson, Fredric, Okun, Michael, Mandel, Ronald

Journal:

Current Gene Therapy

Year:

2009

Language:

english

File:

PDF, 348 KB

english, 2009

46

The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease

Benskey, Matthew J., Perez, Ruth G., Manfredsson, Fredric P.

Journal:

Journal of Neurochemistry

Year:

2016

Language:

english

File:

PDF, 1.29 MB

english, 2016

47

Impact of age and vector construct on striatal and nigral transgene expression

Polinski, Nicole K, Manfredsson, Fredric P, Benskey, Matthew J, Fischer, D Luke, Kemp, Christopher J, Steece-Collier, Kathy, Sandoval, Ivette M, Paumier, Katrina L, Sortwell, Caryl E

Journal:

Molecular Therapy — Methods & Clinical Development

Year:

2016

Language:

english

File:

PDF, 3.49 MB

english, 2016

48

386. rAAV-Mediated Reduction of Alpha-Synuclein in the Substantia Nigra of the African Green Monkey Results in Neurodegeneration

Manfredsson, Fredric P., Redmond, D. Eugene, Lipton, Jack W., Malpass, Ryan M., Collier, Timothy J.

Journal:

Molecular Therapy

Year:

2015

Language:

english

File:

PDF, 341 KB

english, 2015

49

715. Impact of Aging on Recombinant Adeno-Associated and Lentiviral Vector Transduction Efficiency in the Rat Nigrostriatal and Striatonigral Systems

Polinski, Nicole K., Congdon, Lauren, Luke Fischer, D., Manfredsson, Fredric P., Benskey, Matt, Kemp, Chrisopher, Kuhn, Nathan C., Cole-Strauss, Allyson, Steece-Collier, Kathy, Paumier, Katrina L., Li

Journal:

Molecular Therapy

Year:

2015

Language:

english

File:

PDF, 297 KB

english, 2015

50

709. rAAV-Mediated Regulation of Striatal Nurr1 Expression Alters Development and Severity of Levodopa-Induced Dyskinesias in the 6-OHDA Rat Model of Parkinson's Disease

Sellnow, Rhyomi C., Steece-Collier, Kathy, Kanaan, Nicholas M., Sortwell, Caryl E., Collier, Timothy J., Cole-Strauss, Alyson, Lipton, Jack W., Manfredsson, Fredric P.

Journal:

Molecular Therapy

Year:

2015

Language:

english

File:

PDF, 323 KB

english, 2015

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